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Redistribution of flexibility in stabilizing antibody fragment mutants follows Le Chatelier's principle
Title
Redistribution of flexibility in stabilizing antibody fragment mutants follows Le Chatelier's principle
Author
Jacobs, Donald J., Li, Tong, Livesay, Dennis R.
Date Created
2014
Subjects--Topical
Immunoglobulins, Biology
Description
Le Chatelier's principle is the cornerstone of our understanding of chemical equilibria. When a system at equilibrium undergoes a change in concentration or thermodynamic state (i.e., temperature, pressure, etc.), La Chatelier's principle states t...
Rigidity emerges during antibody evolution in three distinct antibody systems: evidence from QSFR analysis of fab fragments
Title
Rigidity emerges during antibody evolution in three distinct antibody systems: evidence from QSFR analysis of fab fragments
Author
Jacobs, Donald J., Li, Tong, Livesay, Dennis R.
Date Created
2015
Subjects--Topical
Immunoglobulins, Biology
Description
The effects of somatic mutations that transform polyspecific germline (GL) antibodies to affinity mature (AM) antibodies with monospecificity are compared among three GL-AM Fab pairs. In particular, changes in conformational flexibility are assess...