Jacobs, Donald J., Ramaprasad, Azhagiya Singam Ettayapuram, Uddin, Shahid, Casas-Finet, Jose
Subjects--Topical
Amino acid sequence, Immunoglobulins
Description
Conformational fluctuations within scFv antibodies are characterized by a novel perturbation-response decomposition of molecular dynamics trajectories. Both perturbation and response profiles are stratified into stabilizing and destabilizing condi...
The effects of somatic mutations that transform polyspecific germline (GL) antibodies to affinity mature (AM) antibodies with monospecificity are compared among three GL-AM Fab pairs. In particular, changes in conformational flexibility are assess...
