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Rigidity emerges during antibody evolution in three distinct antibody systems: evidence from QSFR analysis of fab fragments
Title
Rigidity emerges during antibody evolution in three distinct antibody systems: evidence from QSFR analysis of fab fragments
Author
Jacobs, Donald J., Li, Tong, Livesay, Dennis R.
Date Created
2015
Subjects--Topical
Immunoglobulins, Biology
Description
The effects of somatic mutations that transform polyspecific germline (GL) antibodies to affinity mature (AM) antibodies with monospecificity are compared among three GL-AM Fab pairs. In particular, changes in conformational flexibility are assess...
Redistribution of flexibility in stabilizing antibody fragment mutants follows Le Chatelier's principle
Title
Redistribution of flexibility in stabilizing antibody fragment mutants follows Le Chatelier's principle
Author
Jacobs, Donald J., Li, Tong, Livesay, Dennis R.
Date Created
2014
Subjects--Topical
Immunoglobulins, Biology
Description
Le Chatelier's principle is the cornerstone of our understanding of chemical equilibria. When a system at equilibrium undergoes a change in concentration or thermodynamic state (i.e., temperature, pressure, etc.), La Chatelier's principle states t...
Decomposing dynamical couplings in mutated scFv antibody fragments into stabilizing and destabilizing effects
Title
Decomposing dynamical couplings in mutated scFv antibody fragments into stabilizing and destabilizing effects
Author
Jacobs, Donald J., Ramaprasad, Azhagiya Singam Ettayapuram, Uddin, Shahid, Casas-Finet, Jose
Subjects--Topical
Amino acid sequence, Immunoglobulins
Description
Conformational fluctuations within scFv antibodies are characterized by a novel perturbation-response decomposition of molecular dynamics trajectories. Both perturbation and response profiles are stratified into stabilizing and destabilizing condi...